Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 31, Pages 12904-12907Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja3051052
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Funding
- EPSRC [P/G009546/1, EP/H029575/1]
- AstraZeneca
- EPSRC [EP/F022530/1, EP/G009546/1, EP/H029575/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F022530/1, EP/G009546/1, EP/H029575/1, GR/S23605/01] Funding Source: researchfish
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The characterization of materials by the inherently insensitive method of NMR spectroscopy plays a vital role in chemistry. Increasingly, hyperpolarization is being used to address the sensitivity limitation. Here, by reference to quinoline, we illustrate that the SABRE hyperpolarization technique, which uses para-hydrogen as the source of polarization, enables the rapid completion of a range of NMR measurements. These include the collection of C-13, C-13{H-1}, and NOE data in addition to more complex 2D COSY, ultrafast 2D COSY and 2D HMBC spectra. The observations are made possible by the use of a flow probe and external sample preparation cell to re-hyperpolarize the substrate between transients, allowing repeat measurements to be made within seconds. The potential benefit of the combination of SABRE and 2D NMR methods for rapid characterization of low-concentration analytes is therefore established.
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