Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 24, Pages 9918-9921Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja303904e
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Funding
- Skaggs Institute for Chemical Biology
- NIH [R01 GM062159]
- National Research Foundation of Korea [NRF-2009-352-C00079]
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Bispecific antibodies were constructed using genetically encoded unnatural amino acids with orthogonal chemical reactivity. A two-step process afforded homogeneous products in excellent yield. Using this approach, we synthesized an anti-HER2/anti-CD3 bispecific antibody, which efficiently cross-linked HER2+ cells and CD3+ cells. In vitro effector-cell mediated cytotoxicity was observed at picomolar concentrations.
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