4.8 Article

Copper-Catalyzed Aerobic [3+2]-Annulation of N-Alkenyl Amidines

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 8, Pages 3679-3682

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja2120629

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Funding

  1. Nanyang Technological University
  2. Singapore Ministry of Education

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A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines. These cyclic amidines could be converted into mono-benzyl-protected vicinal diamines by the reduction with aluminum hydride.

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