4.8 Article

Diastereo- and Enantioselective Pd(II)-Catalyzed Additions of 2-Alkylazaarenes to N-Boc Imines and Nitroalkenes

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 44, Pages 18193-18196

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja3083494

Keywords

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Funding

  1. ERC [258580]
  2. EPSRC
  3. Engineering and Physical Sciences Research Council [EP/I004769/1] Funding Source: researchfish
  4. European Research Council (ERC) [258580] Funding Source: European Research Council (ERC)
  5. EPSRC [EP/I004769/1] Funding Source: UKRI

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A chiral Pd(II)-bis(oxazoline) complex was found to be highly effective in promoting the first direct diastereo- and enantioselective addition of alkylazaarenes to N-Boc aldimines and nitroalkenes under mild conditions. Deprotection of Boc-protected products proceeded readily to provide amines in high yields.

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