Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 3, Pages 1416-1418Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja209590u
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Funding
- National Basic Research Program of China (973 Program) [2011CB935701]
- National Natural Science Foundation of China [21121004, 20974030, 91027046]
- NSFC-DFG [TRR61]
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We report a DNA machine that can reversibly regulate target binding affinity on the basis of distance-dependent bivalent binding. It is a tweezer-like DNA machine that can tune the spatial distance between two ligands to construct or destroy the bivalent binding. The DNA machine can strongly bind to the target protein when the ligands are placed at an appropriate distance but releases the target when the bivalent binding is disrupted by enlargement of the distance between the ligands. This capture-release cycle could be repeatedly driven by single-stranded DNA without changing the ligands and target protein.
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