Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 30, Pages 12422-12425Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja305596v
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Funding
- NSF [CHE-1156496]
- Abbott Laboratories
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1156496] Funding Source: National Science Foundation
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The borylation of secondary C-H bonds, specifically secondary C-H bonds of cyclic ethers, with a catalyst generated from tetramethylphenanthroline and an iridium precursor is reported. This borylation occurs with unique selectivity for the C-H bonds located beta to the oxygen atoms over the weaker C-H bonds located alpha to oxygen atoms. Mechanistic studies imply that the C-H bond cleavage occurs directly at the beta position rather than at the alpha position followed by isomerization of a reaction intermediate.
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