Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 20, Pages 8428-8431Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja3036916
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Funding
- University of Edinburgh
- EPSRC
- ERC [258580]
- EPSRC [EP/I004769/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I004769/1] Funding Source: researchfish
- European Research Council (ERC) [258580] Funding Source: European Research Council (ERC)
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Catalytic enantioselective methods for the preparation of chiral azaarene-containing compounds are of high value. By combining the utility of copper hydride catalysis with the ability of C=N-containing azaarenes to activate adjacent alkenes toward nucleophilic additions, the enantioselective reductive coupling of alkenylazaarenes with ketones has been developed. The process is tolerant of a wide variety of azaarenes and ketones, and provides aromatic heterocycles bearing tertiary-alcohol-containing side chains with high levels of diastereo- and enantioselection.
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