Scalable, Divergent Synthesis of Meroterpenoids via Borono-sclareolide

A scalable, divergent synthesis of bioactive meroterpenoids has been developed. A key component of this work is the invention of borono-sclareolide, a terpenyl radical precursor that enables gram-scale preparation of (+)-chromazonarol. Subsequent synthetic operations on this key intermediate permit rapid access to a variety of related meroterpenoids, many of which possess important biological activity.