Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 12, Pages 5556-5559Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja301642c
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Funding
- Creative and Novel Ideas in HIV Research program (CNIHR)
- National Institutes of Health
- International AIDS Society
- National Science Foundation [CHE-0840410, CHE-0946653]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0840410] Funding Source: National Science Foundation
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Amphipathic peptides composed of alternating hydrophobic and hydrophilic amino acids self-assemble into amyloid-inspired, beta-sheet nanoribbon fibrils. Herein, we report a new fibril type that is formed from equimolar mixtures of enantiomeric amphipathic peptides (L- and D-(FKFE)(2)). Spectroscopic analysis indicates that these peptides do not self-sort and assemble into enantiomeric fibrils composed of all-L and all-D peptides, but rather coassemble into fibrils that contain alternating Land D-peptides in a rippled beta-sheet orientation. Isothermal titration calorimetry indicates an enthalpic advantage for rippled beta-sheet coassembly compared to self-sorted beta-sheet assembly of enantiomeric peptides.
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