Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 23, Pages 9644-9656Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja300538s
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Funding
- MICINN (Spain) [CSD-2010- 00065, CTQ2009-14288-C04-01]
- GVA [PROMETEO 2011/008]
- Instituto de Salud Carlos III-Institut Catala de la Salut in Catalonia
- Ajuntament de Valencia
- MICINN
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DNA interaction with scorpiand azamacrocycles has been achieved through modulation of their binding affinities. Studies performed with different experimental techniques provided evidence that pH or metal-driven molecular reorganizations of these ligands regulate their ability to interact with calf thymus DNA (ctDNA) through an intercalative mode. Interestingly enough, metal-driven molecular reorganizations serve to increase or decrease the biological activities of these compounds significantly.
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