Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 6, Pages 2966-2969Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja300031w
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Funding
- National Institutes of Health (National Institute of General Medical Sciences) [R01-GM62871]
- Alexander von Humboldt Foundation
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To date, effective nickel-catalyzed enantio-selective cross-couplings of alkyl electrophiles that bear oxygen leaving groups have been limited to reactions of allylic alcohol derivatives with Grignard reagents. In this Communication, we establish that, in the presence of a nickel/pybox catalyst, a variety of racernic propargylic carbonates are suitable partners for asymmetric couplings with organozinc reagents. The method is compatible with an array of functional groups and utilizes commercially available catalyst components. The development of a versatile nickel-catalyzed enantioselective cross-coupling process for electrophiles that bear a leaving group other than a halide adds a significant new dimension to the scope of these reactions.
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