Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 7, Pages 3532-3541Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja2111459
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- NIH [CA103823]
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Described herein is the first total chemical synthesis of the unique a-subunit of the human glycoprotein hormone (alpha-hGPH). Unlike the biologically derived glycoprotein hormones, which are isolated as highly complex mixtures of glycoforms, alpha-hGPH obtained by chemical synthesis contains discrete homogeneous glycoforms. Two such systems have been prepared. One contains the disaccharide chitobiose at the natural N-glycosylation sites. The other contains dodecamer oligosaccharides at these same sites. The dodecamer sugar is a consensus sequence incorporating the key features associated with human glycoproteins.
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