Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 29, Pages 11912-11915Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja3046958
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Funding
- Medical Research Council [U105181009, UD99999908]
- ERC
- National Science Foundation [CHE-0848398]
- National Science Foundation Graduate Research Fellowship [NSF-0750733]
- MRC [MC_U105181009] Funding Source: UKRI
- Medical Research Council [MC_U105181009] Funding Source: researchfish
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We report the first site-specific genetic encoding of photocaged tyrosine into proteins in mammalian cells. By photocaging Tyr701 of STAT1 we demonstrate that it is possible to photocontrol tyrosine phosphorylation and signal transduction in mammalian cells.
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