Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 24, Pages 10299-10305Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja303436y
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Funding
- Fundacao para a Ciencia e Tecnologia [PTDC/QUI-QUI/118315/2010, Pest-OE/SAU/UI4013/2011, PEst-OE/QUI/UI0100/2011, PTDC/QUI-QUI/099389/2008, SFRH/BD/72376/2010: REDE/1501/REM/2005, Pest-OE/QUI/UI/0612/2011]
- Fundação para a Ciência e a Tecnologia [PTDC/QUI-QUI/118315/2010, PTDC/QUI-QUI/099389/2008] Funding Source: FCT
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Protein modification has entered the limelight of chemical and biological sciences, since, by appending small molecules into proteins surfaces, fundamental biological and biophysical processes may be studied and even modulated in a physiological context. Herein we present a new strategy to modify the lysine's epsilon-amino group and the protein's N-terminal, based on the formation of stable iminoboronates in aqueous media. This functionality enables the stable and complete modification of these amine groups, which can be reversible upon the addition of fructose, dopamine, or glutathione. A detailed DFT study is also presented to rationalize the observed stability toward hydrolysis of the iminoboronate constructs.
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