Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 11, Pages 5326-5330Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja211759n
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Funding
- NSF [0840464]
- Robert A. Welch Foundation [A-0034]
- National Institutes of Health [GM73220]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0840464] Funding Source: National Science Foundation
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Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR and MS and was identified as a triazine in which the pyrimidine ring was oxidatively degraded. A mechanism for toxoflavin degradation based on the identification of the enzymatic product and the recently determined crystal structure of toxoflavin lyase is proposed.
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