Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 43, Pages 17900-17903Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja3090498
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Funding
- L'Oreal USA Fellowship for Women in Science
- NSF [DGE-0707424, CHE-1048804]
- NIH [1R01GM085128, 1DP1GM106413]
- JSPS through the Funding Program for Next Generation World-Leading Researchers [LS103]
- Uehara Memorial Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Direct For Mathematical & Physical Scien [1048804] Funding Source: National Science Foundation
- Division Of Chemistry [1048804] Funding Source: National Science Foundation
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We report the identification and characterization of the caz biosynthetic cluster from Chaetomium globosum and the characterization of a highly reducing polyketide synthase (PKS) that acts in both a sequential and convergent manner with a nonreducing PKS to form the chaetomugilin and chaetoviridin azaphilones. Genetic inactivation studies verified the involvement of individual caz genes in the biosynthesis of the azaphilones. Through in vitro reconstitution, we demonstrated the in vitro synthesis of chaetoviridin A from the pyranoquinone intermediate cazisochromene using the highly reducing PKS and an acyltransferase.
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