4.8 Article

Self-Assembly of a Confined Rhodium Catalyst for Asymmetric Hydroformylation of Unfunctionalized Internal Alkenes

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 6, Pages 2860-2863

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja211455j

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Funding

  1. Schlumberger Foundation's Faculty for the Future
  2. NRSCC
  3. University of Amsterdam

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A chiral supramolecular ligand has been assembled and applied to the rhodium-catalyzed asymmetric hydroformylation of unfunctionalized internal alkenes. Spatial confinement of the metal center within a chiral pocket results in reversed regioselectivity and remarkable enantioselectivities.

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