Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 21, Pages 8798-8801Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja3031054
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- OSU Department of Chemistry
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The combination of a urea catalyst and an a-nitro-a-diazo ester gives rise to a reactive species able to undergo insertion into the N-H bonds of anilines. This new strategy to achieve N-H insertion reactivity is in contrast to typical metal-catalyzed conditions for the generation of carbenoids from alpha-diazocarbonyl compounds. This report includes the extension of the insertion reaction to a three-component coupling for the construction of alpha-amino-alpha-aryl esters in high yield.
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