Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 20, Pages 8356-8359Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja3014924
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Funding
- EPSRC [EP/E055095/1, EP/G048878/1]
- Royal Society
- EPSRC [EP/E055095/1, EP/G048878/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E055095/1, EP/G048878/1] Funding Source: researchfish
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Traditional methods for the construction of nanoparticle arrays and lattices exploit Watson-Crick base pairing of single-stranded DNA sequences as a proxy for self-assembly. Although this approach has been utilized in a variety of applications in nanoassembly, diagnostics, and biomedicine, the diversity of this recognition lexicon, could be considerably increased by developing strategies that recognize the base-pairing landscape of double-stranded DNA (dsDNA) sequences. Herein we describe the first report of programmed gold nanoparticle (GNP) aggregation directed by the recognition of dsDNA sequences using pyrrole-imidazole polyamide-GNP (PA-GNP) conjugates. We demonstrate the reversibility and selectivity of this strategy for forming GNP aggregates in the presence of fully matched dsDNA sequences relative to dsDNA sequences containing one- and two-base-pair mismatches.
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