Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 51, Pages 20605-20608Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja310482z
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Funding
- National Natural Science Foundation of China [81021062, 20902095]
- Foundation from the MOST of China [2012CB721105]
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Ivorenolide A (1), a novel 18-membered macrolide featuring conjugated acetylenic bonds and five chiral centers, was isolated from Khaya ivorensis. The structure of 1 was fully determined by spectroscopic analysis, single-crystal X-ray diffraction, and bioinspired total synthesis. Both compound 1 and its synthetic enantiomer 2 showed potent and selective immunosuppressive activity.
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