4.8 Article

Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 6, Pages 2852-2855

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja2074856

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Funding

  1. Core Research for Evolutional Science and Technology (CREST) of JST
  2. MEXT, Japan
  3. Iketani Science and Technology Foundation
  4. Sumitomo Foundation
  5. Grants-in-Aid for Scientific Research [21603008, 24104002, 22310081] Funding Source: KAKEN

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A transcription regulation system initiated by DNA nanostructure changes was designed and constructed. Using the toehold system, specific DNA strands induced the opening of the tubular structure. A transcription product from the purified tube-attached dsDNA template was observed by addition of DNA strands that were specific for opening the tubular structure.

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