Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 29, Pages 11896-11899Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja304481a
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Funding
- CREST, JST
- JSPS
- Uehara Memorial Foundation
- MEXT through Global COE grant [B01]
- Grants-in-Aid for Scientific Research [24685015] Funding Source: KAKEN
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The first catalytic enantioselective conjugate addition of alkylboron compounds has been achieved. Reactions between alkylboranes and imidazol-2-yl alpha,beta-unsaturated ketones proceeded with high enantioselectivity under the influence of a Cu(I) catalyst system, prepared in situ from CuCl, a new chiral imidazolium salt as a precursor for the N-heterocyclic carbene ligand, and PhOK. Alkylboranes are widely obtained via alkene hydroboration. A variety of functional groups are tolerated in alkylboranes and alpha,beta-unsaturated ketones.
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