Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 21, Pages 8774-8777Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja302363r
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Funding
- National Institutes of Health [IDPIOD006432, R01 R01EB009565]
- University of North Carolina
- University of North Carolina at Chapel Hill
- Liquidia Technologies
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Herein, we report the fabrication of protein (bovine serum albumin, BSA) particles which were rendered transiently insoluble using a novel, reductively labile disulfide-based cross-linker. After being cross-linked, the protein particles retain their integrity in aqueous solution and dissolve preferentially under a reducing environment. Our data demonstrates that cleavage of the cross-linker leaves no chemical residue on the reactive amino group. Delivery of a self-replicating RNA was achieved via the transiently insoluble PRINT protein particles. These protein particles can provide new opportunities for drug and gene delivery.
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