4.8 Article

Total Synthesis and Complete Stereostructure of Gambieric Acid A

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 29, Pages 11984-11987

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja305864z

Keywords

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Funding

  1. MEXT, Japan [21241050, 23681045, 23102016, 24102517]
  2. Astellas Foundation for Research on Metabolic Disorders
  3. Banyu Life Science Foundation International
  4. JSPS
  5. Grants-in-Aid for Scientific Research [24102507, 21241050, 24102517, 23681045, 10J06746, 23102016] Funding Source: KAKEN

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Total synthesis of gambieric acid A, a potent antifungal polycyclic ether metabolite, has been accomplished for the first time, which firmly established the complete stereostructure of this natural product.

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