4.8 Article

Silver-Catalyzed Formal Inverse Electron-Demand Diels-Alder Reaction of 1,2-Diazines and Siloxy Alkynes

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 22, Pages 9062-9065

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja302537j

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Funding

  1. National Institutes of Health [P50 GM086145]
  2. Chicago Community Trust
  3. Chicago Biomedical Consortium

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A highly effective silver-catalyzed formal inverse electron-demand Diets Alder reaction of 1,2-diazines and siloxy alkynes has been developed. The reactions provide ready access to a wide range of siloxy naphthalenes and anthracenes, which are formed in good to high yields, under mild reaction conditions, using low catalyst loadings.

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