Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 32, Pages 13404-13409Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja304119w
Keywords
-
Categories
Funding
- NSFC [20975036, 91027037]
- Program for Cheungkong Scholars and Innovative Research Team in University
- Hunan University 985 fund
Ask authors/readers for more resources
A hydrated get-like pericellular matrix (PCM) covers the surface of all eukaryotic cells and plays a key role in many cellular events, but its effect on nanoparticle internalization has not been studied. Here, using cells with various PCM thicknesses and gold nanoparticles as probes, we demonstrate that, rather than being a barrier to all foreign objects, the PCM can entrap and accumulate NPs, restrict and slow down their diffusion, and enhance their cellular uptake efficiency. Moreover, this newly discovered PCM function consumes energy and seems to be an integral part of the receptor-mediated endocytosis process. These findings are important in understanding the delivery mechanisms of nanocarriers for biomedical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available