4.8 Article

Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from Human Parathyroid Hormone and Analogues

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 36, Pages 15122-15129

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja306637u

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Funding

  1. NIH [CA103823]

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Application of chemical synthesis to gain access to high purity hPTH as well as more stable analogues was accomplished through a menu of extended NCL followed by metal free dethiylation.

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