Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 22, Pages 9406-9409Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja302641e
Keywords
-
Categories
Funding
- MEXT of Japanese Government [20108001, 22245022]
- Ministry of Education, Science and Technology through the National Research Foundation of Korea [R31-2008-10035-0]
- National Research Foundation of Korea [R31-2012-000-10035-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Grants-in-Aid for Scientific Research [22245022, 23655155] Funding Source: KAKEN
Ask authors/readers for more resources
We report the measurement of hole-transfer rate constants (k(ht)) in locked nucleic acid (LNA) and 5-Me-2'-deoxyzebularine (B)-modified DNA. LNA modification, which makes DNA more rigid, caused a decrease of more than 2 orders of magnitude in k(ht), whereas B modification, which increases DNA flexibility, increased k(ht) by more than 20-fold. The present results clearly showed that hole-transfer efficiency in DNA can be increased by increasing DNA flexibility.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available