Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 49, Pages 19714-19717Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja209793b
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Funding
- Natural Sciences and Engineering Research Council of Canada
- le Fonds quebecois de la recherche sur la nature et les technologies du Quebec (FQRNT)
- Canada Research Chairs Program
- Simon Fraser University through the Community Trust
- Center for Self-Assembled Chemical Structures
- Michael Smith Foundation for Health Research
- China Scholarship Council
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We demonstrate a novel strategy enabling the use of a continuous-wave diode near-infrared (NIR) laser to disrupt block copolymer (BCP) micelles and trigger the release of their payloads. By encapsulating NaYF4:TmYb upconverting nanoparticles (UCNPs) inside micelles of poly(ethylene oxide)-block-poly(4,5-dimethoxy-2-nitrobenzyl methacrylate) and exposing the micellar solution to 980 nm light, photons in the UV region are emitted by the UCNPs, which in turn are absorbed by o-nitrobenzyl groups on the micelle core-forming block, activating the photocleavage reaction and leading to the dissociation of BCP micelles and release of co-loaded hydrophobic species. Our strategy of using UCNPs as an internal UV or visible light source upon NIR light excitation represents a general and efficient method to circumvent the need for UV or visible light excitation that is a common drawback for light-responsive polymeric systems developed for potential biomedical applications.
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