Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 40, Pages 15797-15799Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja206538k
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Funding
- NIH-NIGMS [R01 GM090007]
- Boehringer Ingelheim
- DuPont
- Eli Lilly
- Amgen
- University of California, Los Angeles
- ACS Organic Division
- Bristol-Myers Squibb
- Foote Family
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We report the first total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate. Our route features a number of key transformations, including an indolyne cyclization to assemble the [4.3.1]-bicyclic scaffold, as well as a late-stage intramolecular nitrene insertion to functionalize the C11 bridgehead carbon en route to the natural product.
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