Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 5, Pages 1278-1281Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja110094g
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [20975023, 21001033, 20735002]
- National Basic Research Program of China [2010CB732403]
- program for new century excellent talents in university of China [NCET-09-0014]
- National Science Foundation of Fujian Province [2010J06003]
Ask authors/readers for more resources
This communication describes the design of a novel and general bioresponsive controlled-release mesoporous silica (MS) nanoparticles system based on aptamer- target interactions. In this system, the pores of MS were capped with Au nanoparticles modified with aptamer (ATP aptamer in this case). By a competitive displacement reaction, the Au nanoparticles were uncapped in the presence of ATP molecule, and the cargo was released. Our results demonstrated that the aptamer-target interaction may be a promising route for the design of custom-made controlled-release nanodevices specifically governed by target biomolecules. Since aptamers have been obtained for a broad range of targets, including several cancer biomarkers, we believe that this aptamer-based controlled-release system should have an equally broad spectrum of applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available