Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 27, Pages 10629-10637Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja203521e
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [19205021, 20117003, 20689001, 21659204, 21750135]
- Industrial Technology Research Grant Program
- Sankyo Foundation of Life Science
- [22000006]
- Grants-in-Aid for Scientific Research [21750135, 09J10695, 22000006, 23249004, 19205021, 20117003, 21659204] Funding Source: KAKEN
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Hydrogen peroxide is believed to play a role in cellular signal transduction by reversible oxidation of proteins. Here, we report the design and synthesis of a novel fluorescence probe for hydrogen peroxide, utilizing a photoinduced electron transfer strategy based on benzil chemistry to control the fluorescence. The practical value of this highly sensitive and selective fluorescence probe, NBzF, was confirmed by its application to imaging of hydrogen peroxide generation in live RAW 264.7 macrophages. NBzF was also employed for live cell imaging of hydrogen peroxide generated as a signaling molecule in A431 human epidermoid carcinoma cells.
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