Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 29, Pages 11132-11135Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja205081s
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Funding
- Korean Government [2011-0004321, 2010-0018921]
- Ministry of Education, Science and Technology [2010-0028294, 2010-0020209]
- Ajou University
- BK21 Scholarships
- National Research Foundation of Korea [과C6A2404, 2010-0020209, 2009-0093826, 2010-0009280] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We report a ratiometric two-photon probe (SSH-Mito) for mitochondrial thiols. This probe shows a marked blue-to-yellow emission color change in response to RSH, a significant two-photon cross section, good mitochondrial thiol selectivity, low cytotoxicity, and insensitivity to pH over the biologically relevant pH range, allowing the direct visualization of RSH levels in live cells as well as in living tissues at 90-190 mu m depth without interference from other biologically relevant species through the use of two-photon microscopy.
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