4.8 Article

Silver-Mediated Trifluoromethoxylation of Aryl Stannanes and Arylboronic Acids

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 34, Pages 13308-13310

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja204861a

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Funding

  1. NSF [CHE-0952753]
  2. Massachusetts Life Science Center
  3. NIH-NIGMS [GM088237]
  4. Merck
  5. Division Of Chemistry
  6. Direct For Mathematical & Physical Scien [0952753] Funding Source: National Science Foundation

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A silver-mediated cross-coupling of trifluoromethoxide with aryl stannanes and arylboronic acids to give aryl trifluoromethyl ethers is reported. This is the first report of a transition-metal-mediated C-aryl-OCF3 bond formation.

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