Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 15, Pages 5698-5700Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja200444t
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Funding
- Korean Government [2010-0016997, 2010-0018921]
- Ministry of Education, Science, and Technology [2010-0028294, 20100020209]
- Ajou University
- BK21
- National Research Foundation of Korea [2007-0056632, 과09A1514, 2009-0065783, 2009-0093826, 과C6A2404] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We report a two-photon probe (SZn-Mito) for mitochondrial zinc ions ([Zn2+](m)). This probe shows a 7-fold enhancement of two-photon-excited fluorescence in response to Zn2+ with a dissociation constant (K-d(TP)) of 3.1 +/- 0.1 nM and pH insensitivity in the biologically relevant range, allowing the detection of [Zn2+](m) in a rat hippocampal slice at a depth of 100-200 mu m without interference from other metal ions through the use of two-photon microscopy.
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