Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 18, Pages 6886-6889Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja111137n
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Funding
- National Basic Research Program of China [2010CB933504]
- National Natural Science Foundation of China [90913006, 21077068]
- National Cancer Institute [P30CA027165]
- American Lebanese Syrian Associated Charities (ALSAC)
- St. Jude Children's Research Hospital
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We report a generic approach for identification of target proteins of therapeutic molecules using nanoprobes. Nanoprobes verify the integrity of nanoparticle-bound ligands in live cells and pull down target proteins from the cellular proteome, providing very important information on drug targets and mechanisms of action. As an example, target proteins as a-tubulin and HSP 90 have been identified and validated.
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