4.8 Article

Rhodium(III)-Catalyzed Arylation of Boc-Imines via C-H Bond Functionalization

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 5, Pages 1248-1250

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja109562x

Keywords

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Funding

  1. NIH [GM069559]
  2. Office of Energy Research, Office of Basic Energy Sciences, Chemical Sciences Division, U.S. Department of Energy [DE-AC02-05CH11231]
  3. Eli Lilly Fellowship
  4. Deutsche Forschungsgemeinschaft (DFG) [Ta 733/1-1]

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The first rhodium-catalyzed arylation of imines proceeding via C-H bond functionalization is reported. Use of a non-coordinating halide abstractor is important to obtain reactivity. Aryl-branched N-Boc-amines are formed, and a wide range of functionality is compatible with the reaction.

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