4.8 Article

Asymmetric Synthesis of Ageliferin

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 39, Pages 15350-15353

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja207386q

Keywords

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Funding

  1. NIH (NIGMS) [R01-GM079554, 4R01-GM079554-S1]
  2. Welch Foundation [I-1596]
  3. UT Southwestern

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We describe herein an asymmetric synthesis of ageliferin. A Mn(III)-mediated oxidative radical cyclization reaction was used as the key step to construct the core skeleton of this pyrrole-imidazole dimer. This approach resembles the biogenic [4 + 2] dimerization in an intramolecular fashion.

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