Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 8, Pages 2414-2417Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja111583e
Keywords
-
Categories
Funding
- NSF [CHE-0910604]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0910604] Funding Source: National Science Foundation
Ask authors/readers for more resources
A stereodynamic probe containing a central 1,4-di(phenylethynyl)benzene rod and two 2-formylphenylethynyl branches has been prepared through a series of Sonogashira cross-coupling reactions with 62% overall yield. This CD silent diarylacetylene-based framework carries two terminal aldehyde groups and provides a strong chiroptical response to substrate-controlled induction of three chiral axes upon diimine formation. The chiral amplification results in intense Cotton effects that can be used for in situ ICD analysis of the absolute configuration and ee of a wide range of amines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available