Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 10, Pages 3401-3409Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja1063058
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Funding
- Ministry of Education, Culture, Sports Science and Technology of Japan [22000006, 20689001, 21659204]
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
- Sankyo Foundation of Life Science
- Grants-in-Aid for Scientific Research [22000006, 20689001, 21659204] Funding Source: KAKEN
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Novel ratiometric, near-infrared fluorescent pH probes with various pK(a) values have been designed and synthesized on the basis of aminocyanine bearing a diamine moiety, and their photochemical properties were evaluated. Under acidic conditions, these pH probes showed a 46- to 83-nm red shift of the absorption maximum. This change is sufficiently large to permit their use as ratiometric pH probes, and is reversible, whereas monoamine-substituted aminocyanines showed irreversible changes because of their instability under acidic conditions. Furthermore, the pK(a) values of these probes can be predicted from the calculated pK(a) values of the diamine moieties, obtained from the SciFinder database. This design strategy is very simple and flexible, and should be applicable to develop NIR pH probes for various applications.
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