Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 34, Pages 13248-13251Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja204331w
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Funding
- NIH NIGMS [R01 GM073932]
- DAIICHI SANKYO Co., Ltd.
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A chiral Bronsted acid has been developed from a cationic gold(I) disphosphine complex in the presence of alcoholic solvent and applied to the enantioselective protonation reaction of silyl enol ethers of ketones. Various optically active cyclic ketones were obtained in excellent yields and high enantioselectivities, including cyclic ketones bearing aliphatic substrates at the a-position. Furthermore, the application of this Bronsted acid was extended to the first Bronsted add-catalyzed enantioselective protonation reaction of silyl enol ethers of acyclic substrates, regardless of their E/Z ratio.
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