4.8 Article

Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 4, Pages 680-682

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja108527y

Keywords

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Funding

  1. National Basic Research Program of China (973 Program) [2010CB933504]
  2. National Natural Science Foundation of China [21077068]
  3. National Cancer Institute [P30CA027165]
  4. American Lebanese Syrian Associated Charities (ALSAC)
  5. St. Jude Children's Research Hospital

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We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.

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