Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 7, Pages 2031-2033Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja109686v
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Funding
- Camille and Henry Dreyfus Foundation
- Research Corporation
- Towsley Foundation
- NSF [CHE-0922623]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0922623] Funding Source: National Science Foundation
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The rhodium-catalyzed intramolecular carboacylation of quinolinyl ketones serves as an ideal subject for the mechanistic study of carbon-carbon bond activation. Combined kinetic and NMR studies of this reaction allowed the identification of the catalytic resting state and determination of the rate law, C-12/C-13 kinetic isotope effects, and activation parameters. These results have identified the activation of a ketone-arene carbon-carbon single bond as the turnover-limiting step of catalysis and provided quantitative detail into this process.
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