Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 43, Pages 17513-17518Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja208456k
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Funding
- NIH [R01CA142746]
- NSF [DMR 0820492]
- HFSP [RGP0056/2008]
- Brandeis University
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The integration of nucleobase, amino acid, and glycoside into a single molecule results in a novel class of supramolecular hydrogelators, which not only exhibit biocompatibility and biostability but also facilitate the entry of nucleic acids into cytosol and nuclei of cells. This work illustrates a simple way to generate an unprecedented molecular architecture from the basic biological building blocks for the development of sophisticated soft nanomaterials, including supramolecular hydrogels.
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