Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 28, Pages 10990-10998Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja204200x
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Funding
- EPSRC [EP/F066104/1]
- Kano State Government Nigeria
- MacArthur Foundation
- Bayero University
- Nigerian Petroleum Technology Fund
- Higher Education Commission of Pakistan
- EU
- BBSRC [BB/I003355/1, BB/E007791/1] Funding Source: UKRI
- EPSRC [EP/F066104/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I003355/1, BB/E007791/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/F066104/1] Funding Source: researchfish
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The biosynthesis of the fungal metabolite tenellin from Beauveria bassiana CBS110.25 was investigated in the presence of the epigenetic modifiers 5-azacytidine and suberoyl bis-hydroxamic acid and under conditions where individual genes from the tenellin biosynthetic gene cluster were silenced. Numerous new compounds were synthesized, indicating that the normal predominant biosynthesis of tenellin is just one outcome out of a diverse array of possible products. The structures of the products reveal key clues about the programming selectivities of the tenellin polyketide synthase.
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