Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 41, Pages 16418-16421Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja207835w
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- St. John's College, Oxford
- Brazillian Research Council (CNPq)
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The synthesis of the potent antitumor agent (+/-)-streptonigrin has been achieved in 14 linear steps and 11% overall yield from ethyl glyoxalate. The synthesis features a challenging ring-closing metathesis reaction, followed by elimination and aromatization, to furnish a key pentasubstituted pyridine fragment.
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