Ligand-Promoted C-3 Selective C-H Olefination of Pyridines with Pd Catalysts

Pd-catalyzed C-3 selective olefination of pyridines is developed for the first time using 1,10-phenanthroline as the ligand. This finding provides a novel disconnection for the synthesis of pyridine-containing alkaloids and drug molecules as well as a new approach for developing Pd-catalyzed C H functionalizations of pyridines.