Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 32, Pages 12350-12353Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja2033734
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Funding
- National Institutes of Health [GM087981]
- Robert A. Welch Foundation [A-1121]
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Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/beta-turn/sheet motif.
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