4.8 Article

Luminescent Ruthenium(II) Polypyridyl Functionalized Gold Nanoparticles; Their DNA Binding Abilities and Application As Cellular Imaging Agents

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 133, Issue 40, Pages 15862-15865

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja2061159

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Funding

  1. Science Foundation Ireland (SFI RFP)
  2. HEA PRTLI Cycle 4
  3. Irish Research Council for Science, Engineering and Technology (IRCSET)
  4. TCD

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The synthesis and photophysical and biological investigation of Ru(II)-polypyridyl stabilized water-soluble, luminescent gold nanoparticles (AuNPs) are described. These structures bind to DNA and undergo rapid cellular uptake, being localized within the cell cytoplasm and nucleus within 4 h.

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