Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 13, Pages 4550-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja100746d
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Funding
- NIGMS
- National Institutes of Health
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Disassembling a supramolecular assembly and releasing the contents of the assembly in response to a stimulus are important goals of supramolecular chemistry. When proteins are used as the stimulus, the biological relevance of the suprannolecular event dramatically increases. Although there have been efforts in which such disassembly has been achieved using enzymatic action, such events based on ligand-receptor interactions have been very limited. Here we demonstrate protein-binding-induced disassembly of dendrimer-based amphiphilic nanocontainers. We show that this disassembly is selective to the targeted protein and that the disassembly event causes a release of the sequestered guest molecules. We propose that the disassembly is caused by alteration of the hydrophilic-lipophilic balance caused by the protein binding.
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